The program of the ABPP 2019 symposium will be posted when available. The meeting will start on Wednesday March 27, 2019 at noon with registration. The official welcome and first talks will start at 1.45 pm. The meeting will end on Friday March 29, 2019 at lunchtime.
The preliminary program is listed below.
Wednesday March 27, 2019
| 12:00 | Registration, welcome lunch, poster mounting |
| 13:30 | Introduction by organizers |
| 13:45 | Thematic session 1: ABPP in imaging and diagnostics Session chair: Steven Verhelst |
| 13:45 – 14:30 | Matt Bogyo (Stanford University) – keynote 1 |
| 14:30 – 14:45 | Filipe Elvas (University of Antwerp) – Development and evaluation of positron emission tomography (PET) probes for imaging of caspase-3 activity |
| 14:45 – 15:15 | Elena Goun (EPFL) |
| 15:15 | Coffee break |
| 15:45 | Thematic session 2: Novel applications in ABPP Session chair: Megan Wright |
| 15:45 – 16:00 | Marta Artola (Leiden University) – Rational design of conformational chaperones: from covalent cyclic sulfates to reversible cyclic sulfamidates |
| 16:00 – 16:15 | Suravi Chakrabarty (KU Leuven) – Photoactivatable inhibitors and ABPs for proteases |
| 16:15 – 16:30 | Floris van Dalen (Radboud University Nijmegen) – Targeted delivery of a quenched activity-based probe |
| 16:30 – 17:00 | Marcin Drag (Wroclav University of Technology) – Mass cytometry compatible activity-based probes (TOF-probes) to decipher proteolytic enzymes fingerprint in the activome |
| 17:00 | Poster session I (odd numbers) |
| 19:00 | End of scientific part of day 1 & departure for conference dinner |
| 19:30 | Conference dinner in Faculty Club |
Thursday March 28, 2019
| 9:00 | Thematic session 3: ABPP in bacteria and pathogens | ||||||||||||||||||||||||||||||
| 9:00 – 9:30 | Stephan Sieber (TU Munich) – Chemical proteome mining to fight multiresistant bacteria | ||||||||||||||||||||||||||||||
| 9:30 – 10:00 | Michael Meijler (Ben Gurion University of the Negev) – Chemical Information Exchange as a Regulator of War and Love Between Species | ||||||||||||||||||||||||||||||
| 10:00 – 10:15 | Christian Lentz (Helmholtz Centre Braunschweig) – Single-cell phenotypic characterization of the bacterial pathogen Staphylococcus aureus with fluorescent activity-based probes | ||||||||||||||||||||||||||||||
| 10:15 – 10:30 | Thomas Boettcher (University of Konstanz) – Live-cell profiling for inhibitors of quinolone biosynthesis | ||||||||||||||||||||||||||||||
| 10:30 | Coffee break | ||||||||||||||||||||||||||||||
| 11:00 | Thematic session 4: ABPP and proteomics Session chair: Pieter Van Der Veken | ||||||||||||||||||||||||||||||
| 11:00 – 11:15 | Isabel Wilkinson (Oxford University) – Target identification studies of a utrophin modulator for treatment of Duchenne muscular dystrophy | ||||||||||||||||||||||||||||||
| 11:15 – 11:30 | Martin Walko (University of Leeds) – New Protein Labels for Tag-Transfer Photocrosslinking | ||||||||||||||||||||||||||||||
| 11:30-11:45 | Stephan Hacker (TU Munich) – Residue-specific mapping of ligandable sites in the bacterial proteome | ||||||||||||||||||||||||||||||
| 11:45 – 12:00 | Kristyna Blazkova (Czech Academy of Sciences) – The identification of protein targets using probes that combine synthetic nanoparticles with stochastic photomodification of bioactive small molecules | ||||||||||||||||||||||||||||||
| 12:00 – 12:45 | Ben Cravatt (The Scripps Research Institite) – keynote 2
| 12:45 |
Lunch |
13:45 |
Thematic session 5: ABPP application in biology |
13:45 – 14:00 | Lindsey Lelieveld (Leiden University) – Applications of β-glucosidase ABPs in embryonic and adult zebrafish | 14:00 – 14:15 | Joanna Misas Villamil (MPI Cologne)- PLCPs as hubs in plant immunity: case studies using ABPP | 14:15-14:30 | Wouter Kallemeijn (Imperial College London) – Validation and invalidation of chemical probes for the human N myristoyltransferases | 14:30-14:45 | Geronimo Heilmann (University Duisburg-Essen)- Hydrolase-screening in secretomes of thermophilic fungis | 14:45-15:00 | Sebastiaan Koenders (Leiden University)– Visualizing vitamin A metabolism | 15:00-15:15 | Robert Macsics (TU Munich)- Repurposing human kinase inhibitors to create an antibiotic active against drug resistant Staphylococcus aureus | 15:15 |
Coffee break |
15:45 |
Thematic session 6: Chemical probes for PTMs and PTM processing enzymes Session chair: Robin Bon |
15:45-16:15 | Ed Tate (Imperial College London) – Probes and drugs targeting post-translational modification | 16:15-16:30 | TBA | 16:30-17:00 | Joanna McGouran (Trinity College Dublin) – Activatable probes targeting deubiquitinating enzymes | 17:00 |
Poster session II (even numbers) |
19:00 |
Free evening |
|
Friday March 29, 2019
| 9:00 | Thematic session 7: Design & synthesis of novel chemical probes Session chair: TBA |
| 9:00 – 9:30 | Annemieke Madder (Ghent University) – Furan peptides and oligonucleotides as ROS-triggerable proreactive probes for nucleic acid and protein target identification |
| 9:30 – 9:45 | Gary Tin (University of Toronto) – Electronic Tuning of PentaFluoroBenzeneSulfonamide (PFBS) warheads |
| 9:45 – 10:00 | Berend Gagestein (Leiden University) – Probing lipid signaling molecules |
| 10:00 – 10:30 | Megan Wright (University of Leeds) – Chemical tools to study signal-receptor interactions at the host-microbe interface |
| 10:30 | Coffee break |
| 11:00 | Thematic session 7 – continued: |
| 11:00 – 11:15 | Elma Mons (Leiden University Medical Center) – The Thiol Reactivity of Terminal Alkynes in Small Molecule Inhibitors of CatK |
| 11:15 – 11:30 | Luis Carvalho (University of Lisboa) – Activity-based Protein Profiling of Serine Hydrolases using 4-Oxo-β-Lactams |
| 11:30 – 12:15 | Hermen Overkleeft (Leiden University) – Keynote 3 Activity-based glycosidase profiling: applications in biomedicine and biotechnology |
| 12:15 | poster prize awards |
| 12:25 | Thanks and goodbye by organizers; announcement of ABPP2020 |
| 12:45 | Lunch and departure |